Oral cancer accounts for 2.9% of all U.S. cancer cases, with an estimated 51,000 new diagnoses and 10,000 fatalities annually. It commonly affects the tongue, tonsils, gums, and mouth lining, with men over 50, heavy smokers, and frequent drinkers at higher risk. Additional factors include UV exposure, GERD, poor diet, and HPV. Early detection through regular dental screenings improves outcomes. During a comprehensive exam, a dentist assesses medical history and checks for signs of oral cancer in the mouth, head, and neck.